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About Glenmark Pharmaceuticals Ltd. Glenmark Pharmaceuticals Ltd. (BSE: 532296 | NSE: GLENMARK) is an innovation-driven global pharmaceutical company with a presence across Specialty, Generics and OTC businesses. NONS for COVID-19 Treatment [COVID-19]. So you use it in your nose like you use hand sanitizer on your hands, to kill COVID and other viruses. NONS protects users from viruses that enter the body through the upper nasal pathways. If you've used Enovid or another COVID-19 nasal spray, what was your experience? Then you insert the bottle into one nostril, press your finger against your other nostril to close it off and pump one spray into your nose. Nitric Oxide Nasal Spray (NONS) is currently sold as a medical device in Thailand, Hong Kong, Singapore, Indonesia, Israel, and Bahrain. The study was carried out at 20 clinical sites across India, evaluating 306 participants who had mild Covid-19 symptoms, approximately 46 per cent of of whom were vaccinated. Of the 422 in the control group, 108 participants tested positive (25.

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Dr. Regev says using Nitric Oxide Nasal Spray (NONS) in the nose is like using hand sanitizer on the hands. The robust double-blind trial demonstrated significant efficacy and remarkable safety of NONS. Nitric oxide has been used medically for years and is known to be safe, but this new use has had some challenges in getting regulatory approval. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Become a TravelSort Client and Book 5-Star Hotels with Virtuoso or Four Seasons Preferred Partner Benefits. One company is researching a nasal spray that induces nasal cells to produce NO, in the hopes that it may serve as a prophylactic. Unfortunately just after I ordered it my husband felt unwell and tested positive for COVID. Storage: Store at room temperature. ENOVID is approved as a nasal spray device in Israel with registration number 34390001 and with the following indication for use: "ENOVID is a nasal spray device intended for use as a proactive mechanical and chemical barrier against viruses within the nasal cavity. We have no connection with the company other than as a customer. Nitric Oxide Nasal Spray (NONS) kills viruses on contact so it makes sense to use it after a possible exposure to kill any virus that you breathed in to your nose. VANCOUVER, British Columbia — SaNOtize Research & Development Corp., ("SaNOtize"), a Canadian anti-infective-focused therapeutics company, today announced an oversubscribed $24 million Series B funding to advance its nitric oxide-based therapeutics pipeline. Photo: Olemedia, Getty Images.

Because using NONS when you have COVID reduces the time it takes to become COVID negative by rapid test, it should reduce how infectious you are. SaNOtize was founded in 2017 by Dr. Regev and Chief Scientific Officer and Co-Founder, Chris Miller, PhD to leverage the antimicrobial properties of nitric oxide (NO), a naturally occurring molecule known to have antibacterial, antifungal, and antiviral properties. SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial. There is no biochemical, pharmacokinetic or physical difference between them. Based on listening to the podcast interview with the scientists it seems the 2 spray dose is so that the spray covers the nostril of any person. For more information, visit View source version on Contacts. Nitric Oxide Nasal Spray, is designed to kill the COVID-19 virus in the upper airways. 1 years, 0 months, 1 days.

The study was conducted by Glenmark in 306 vaccinated and non-vaccinated adults of symptomatic mild COVID-19 across 20 clinical sites in India. Luckily, a number of research groups have been working on this very issue, developing novel methods to generate NO for new therapeutic applications. Although initial data is promising, this study will help clarify the effects and potential of nitric oxide in COVID-19 treatment. 6% in the control group (P<0. Date of REC Opinion. So just using a nasal spray with these ingredients might be helpful to reduce symptoms if you have COVID. 12/29/22 Update: A retailer we've purchased from, IsraelPharm, is offering 10% off 3 boxes of Enovid through 12/31/22. During the clinical study, except for mild nasal discomfort, no major side effects occurred with the use of Nitric Oxide Nasal Spray. Read the latest updates in our dedicated coronavirus section.

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DEAR DR. ROACH: A doctor friend suggested I purchase a nitric oxide nasal spray from Israel. In India, NONS received an emergency use approval by the Central Drugs Standard Control Organization (CDSCO) for treatment of adult patients with COVID-19 who have a risk of progression of the disease. In a recent Phase 3 study, NONS shortened the time to negative PCR and demonstrated a reduction in SARS-CoV-2 viral burden in high-risk COVID-19 patients by 94% and 99% within 24 and 48 hours of treatment, respectively. How Does This Anti COVID Nasal Spray Work? Exploratory evaluation of NONS in prevention of infection in immediate contacts of these COVID-19 patients was also evaluated. The company is also in ongoing dialogue with additional global regulatory bodies, including the Medicines and Healthcare Products Regulatory Agency for Exceptional Use Authorization in the UK, the Food and Drug Administration in the USA, and the Ministry of Health, Labor and Welfare in Japan. Bluish lips or skin. Only a few of people in a study (6. This is an asset because monoclonal antibody treatments are not only very specific, but also expensive and need intravenous administration in a clinical setting. One of its applications, an NO-releasing nasal spray, has shown promise against SARS-CoV-2 and its variants in both laboratory and clinical studies, including rapid viral load reduction in a Phase 3 study. "We are delighted to participate in this important funding round for SaNOtize, whose breakthrough antiviral nasal spray continues to gain traction globally as the clinical results mount and NONS gains regulatory approval in more countries, as it is here in Israel, " said OurCrowd CEO Jon Medved. Discard sprayer at the earlier of the expiration date or 30 days after the first opening.

A central lesson might be that we need to move away from the idea of managing a single "bug" with a single tool – it will take a collection of approaches working in concert to fully wrap our arms around a given problem. Result shown in lab studies against viruses like SARS-CoV-2, H1N1, RSV. Glenmark Pharmaceuticals has partnered with SaNOtize to manufacture, market, and distribute NONS to India, Singapore, Malaysia, Hong Kong, and more. Unusual tiredness or weakness. Global Approvals for NONS. ENOVID is not a drug or a medicine. When applied over nasal mucosa, the spray works as a physical as well as a chemical barrier against the virus, thereby averting the viral incubation and spreading to the lungs. But are there side effects to using Nitric Oxide Nasal Spray (NONS)? If you are sensitive to any of the ingredients, do not use this product! Glenmark to market NONS under the brand name FabiSpray, " the company said in a statement. Use of inhaled nitric oxide is not indicated in geriatric patients. In February, SaNOtize announced that its nasal spray product was approved for sale in India after said trials proved it can reduce viral load in people with mild cases of coronavirus.

Among the 203 participants who used NONS, 13 tested positive (6. The multicentre, parallel-arm, double-blind trial analysed the safety and efficacy of NONS against saline nasal spray enrolling 306 non-hospitalised patients across 20 clinical sites in the country. This medicine is usually given for up to 14 days or until your baby is ready to be weaned from nitric oxide treatment. Unfortunately, the kind of study needed to show effectiveness at preventing the disease is extremely large and expensive. The enovid spray has these ingredients: - Sodium Choride. Do not take other medicines unless they have been discussed with your doctor. May increase risk for more serious side effects. One academic research group found that an NO-releasing nanoparticle platform can greatly reduce the incidence of C. albicans infection and accelerate healing in a mouse model of burn wounds. NO has also been used to treat viral lung infections in people with cystic fibrosis. Do not share sprayer with other people to avoid transmission of viruses or germs from person to person. "The results of this study using real-world evidence suggest NONS is an effective self-administered tool to prevent COVID-19 infection, even after high-risk exposure, " said lead author Jarinratn Sirirattawan, MD, Assistant Professor, Srinakharinwirot University, Ongkharak site, Thailand. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

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So Far COVID Negative. "Our clinical and observational studies found NONS to be safe and effective at both treating and preventing COVID-19, even amid delta and omicron surges. The therapy's active ingredient is nitric oxide (NO), a natural nanomolecule produced by the human body with proven anti-microbial properties shown to have a direct effect on the –replication of SARS-CoV-2. Key secondary endpoints including clinical improvement assessed by WHO Clinical Progression Scale Score and extent/rapidity of virologic recovery was demonstrated in patients using NONS. Dr. Regev has PhD in Biochemistry, 30 years of research experience, with 12 years in the field of nitric oxide research. What are the Ingredients in NONS? "There is currently a lack of an antiviral therapy that is effective against COVID-19 and its variants, can prevent or shorten the course of the disease, reduce damage, lower the severity of COVID-19, and can be made widely and readily available to the public. People with COVID infections using the spray also were more likely to have no symptoms at the end of the 16 days study.

For a lot of people infected by COVID-19, they exhibit mild symptoms: dry cough, mild fever, tiredness, loss of smell. Additionally, the majority of patients included in the study were found to be infected with the UK variant of SARS-CoV-2, which has been a variant of concern in terms of treatments. The median time to virological cure was three days in the NONS group and seven days in the placebo group after start of treatment (four days sooner). It breaks down the viral proteins that the virus needs to enter the cells through through angiotensin converting enzyme 2 (ACE-2), and it also interferes with proteins the virus needs to replicate.

As a physical and chemical barrier to airborne viruses, VirX is designed to block also COVID-19 viruses, just as other respiratory viruses that can be transmitted through the air. Your baby's doctor will measure how much methemoglobin is in your baby's blood while receiving this medicine. We can't prove it, but we suspect our family's use of Enovid helped his odds. But the Covid-19 pandemic presented a new set of challenges, showing us both what's possible in terms of speed of response and what we need to do better to prepare for the next one. For this medicine, the following should be considered: Allergies. "We are pleased to have conducted this crucial trial in the NHS and now hope that regulators will play their part in arming the public in the battle against this devastating disease.

"Almost every week a colleague or collaborator in the field brings up the significant global unmet need and we acknowledge together the potential NONS has in protecting communities across the world from COVID-19. Manufactured by: Glenmark Pharmaceuticals Ltd. India Stock: In addition to viral pandemics, AMR is one of the most urgent global health concerns: Projections suggest that AMR may kill 10 million people annually by the year 2050 and cost $100 trillion globally.