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The Sickle's home constellation of Leo the Lion is one of the few whose pattern of stars looks quite a bit like what it was named for. One of the few stars with a name that comes from Latin, Regulus means little king. Algenubi is the fifth-brightest star in Leo, and its name means the southern star of the Lion's head. In 2010, a planet was discovered around the primary star of the double star system. Continuing up the Sickle we come to Adhafera (or Zeta Leonis), which marks the back of Leo's head and part of the Lion's mane. Sickles used to be standard farm equipment, used in reaping. The stellar lion has been identified for ages. The star is also called Cor Leonis, the Lion's Heart. 8 times that of Jupiter but an orbit closer to its home star, like Earth is to the sun.

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Algenubi is transitioning from a main sequence star to a red giant. Because of this, Regulus is often visited by the moon and planets, and sometimes the moon even occults, or passes in front of the star, in a type of eclipse. It's what's called an asterism, a small and recognizable grouping of stars, one of the easier patterns to spot in the night sky. The planet has a mass 8. Leo was important to Egyptians because the annual flooding of the Nile occurred when the sun was in front of the stars of the Lion. A super-metal-rich giant, it has about 70 percent more iron than the sun. Rasalas means the eyebrows. The star is classified as a dwarf with a bluish white hue. The speed and shape affect the star's temperature, with the equator registering at about 10, 200 kelvin (18, 000 degrees Fahrenheit) but the poles at 15, 400 K (27, 999 F). The next star up in the Sickle is Algieba (or Gamma Leonis), located in the Lion's mane. 3, making it the faintest of 1st-magnitude stars and the 21st-brightest star overall. Ancients Persians, Turks, Syrians, Hebrews and Babylonians all saw a lion with its triangular body at the rear and great head and shoulders in the sickle-shaped backwards question mark pattern. The famous Leonid meteor shower in November radiates from a point near Algieba. Rasalas (or Mu Leonis) is the next star up marking the top of the Lion's head.

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9 from 90 light-years away. At such a great distance, it's no surprise to learn that it's 28 times larger than the sun, allowing us to see it from across the great expanse. The Sickle is a hallmark of spring skies in the Northern Hemisphere, but you can see it at other times of the year, too. Regulus lies 79 light-years away and is estimated to be about 250 million years old. Also close to the ecliptic, the star is occasionally occulted by the moon, and it winks out twice, showing that it is not a single star.

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Algenubi shines at magnitude 2. The two stars are two different classifications, making them appear a fantastic orangish-yellow and yellowish-green through telescopes. A fun fact about Regulus that is particularly noteworthy to stargazers is that it's the closest star to the ecliptic, or path of the planets and moon across our sky. Adhafera was a dwarf and will eventually become a different class of giant with a diameter larger than Earth's orbit. Greeks saw Leo as the great Nemean Lion, killed by Hercules as the first of his 12 labors. This star shines at magnitude 3. Leo's brightest star is Regulus. What is the Sickle in Leo? Regulus is magnitude 1. Adhafera's name means "locks of hair, " which works for a star in a lion's mane, even though it was accidentally given to this star instead of one in the neighboring constellation of Berenice's Hair (Coma Berenices). Bottom line: The famous Sickle in Leo is an easy-to-spot backward question mark shape that marks the head and shoulders of the constellation of Leo the Lion.

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The star pattern known as The Sickle in the constellation Leo the Lion looks like a backward question mark. Leo's Sickle, which represents the head and shoulders of the Lion, is formed by six stars: Epsilon, Mu, Zeta, Gamma, Eta, and Alpha Leonis (the last one is better known as Regulus, or Cor Leonis, the Lion's Heart). We are seeing it at a short stage in its life cycle. To get to know the Sickle a bit better, let's start at the most prominent of its stars, Alpha Leonis, or Regulus, marking the bottom of the Sickle or the period in the backward question mark.

Algieba is the second-brightest Sickle star and shines at magnitude 1. This puts the star three times farther away from us than Regulus. Regulus is the brightest star in not only the Sickle but the constellation of Leo and was given its name by Copernicus. Eta is a 4th-magnitude star (magnitude 3. This may be because Rasalas is expanding and eating its metal-rich inner planets.

Regulus has the fastest rotation of any 1st-magnitude star at about 200 miles per second (317 km/sec), which contorts its shape from spherical to bulging.

Chi Shao (Radix Paeoniae Rubra), 8. As such Ge Xia Zhu Yu Tang is used by TCM practitioners to treat four different patterns which we describe below. Daina, A., Michielin, O., and Zoete, V. (2019). Zhang et al., 2021), Paeoniae Radix Rudra (the root of Paeonia lactiflora Pall. Share your opinion with other customers Leave my review. There are also emotional issues like mood swing, depression or irritability. Dimethyl Fumarate Targets GAPDH and Aerobic Glycolysis to Modulate Immunity. Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy. Hepatitis B x antigen (HBxAg) promoted chronic infection by preventing immune mediated apoptosis of infected hepatocytes, promoting the establishment and persistence of fibrosis and cirrhosis preceding the development of HCC, and promoting the remodeling of extracellular matrix during tumor progression (Feitelson et al., 2009). ALT, AST, and ALP of serological index rats were increased after 8 weeks CCl4 modeling. Feitelson, M. A., Reis, H. M., Tufan, N. L., Sun, B., Pan, J., and Lian, Z. Infertility, history of miscarriage. Concretions and accumulations. 0 statistical software package.

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Carthami Flos (Honghua in Chinese, No. Disperses Cold and Warms the Kidneys. OGEs overlapped genes. Putative Roles of Hepatitis B X Antigen in the Pathogenesis of Chronic Liver Disease. Invigorates the Blood, unblocks menstruation, opens the channels, dispels Blood Stasis and alleviates pain. Zhi Qiao (Fructus Aurantii), 6. Palpable abdominal masses.

GXZY suppressed proliferation and migration and expression of key target genes of LX-2 cells. Ge xia zhu yu tang bee. The potential therapeutic effects of GXZY on LC may benefit from further studies on clinical trials of LC patients with GXZY treatment. Symptoms: Lumps Tremor Numbness Dark face Dizziness Purple lips Purple nails Blotchy skin Restlessness Itching scalp Painful period Abdominal mass Scanty periods Abdominal pain Abdominal masses Skin capillaries Hesitant periods Tendency to bleed Premenstrual pain Dark colored blood Traumatic swelling Shoulder stiffness Absence of menstruation Boring fixed stabbing pain Frequent bleeding episodes Dark clots in menstrual blood Abdominal distention and fullness. We inputted the OGEs into the STRING database () (Szklarczyk et al., 2019) with the species limited to "Homo sapiens" and confidence scores ≥0.

This standard dosage may be increased or decreased. All statements made. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Sanctions Policy - Our House Rules. Regulates Stagnant Qi and reduces associated pain. The increased expression of MMP9 promotes the migration of LX-2 cells, which is related to upregulating phosphorylation of IκBα and p65 protein (Xu et al., 2016). Qi and/or blood deficiency w/irregular pluse or palpitations (Zhi Gan Cao Tang)…. Ru, J., Li, P., Wang, J., Zhou, W., Li, B., Huang, C., et al.

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For legal advice, please consult a qualified professional. In general Gan Cao's main actions are as follows: "Tonifies the Basal Qi and nourishes the Spleen Qi. The serum of rats was taken to detect the biochemical indexes of ALT, AST, and ALP. Custom Formula Order. Baicao Acu & Moxa Essences. Formula explanation: Within this formula, Xiang Fu, Wu Yao, and Zhi Ke move the qi and dispel. Patients with Stomach Blood Stagnation typically exhibit wiry (Xian) pulses as well as Purple. PloS one 7 (4), e34460. My patient does present the signs and symptoms of: Qi stagnation Yes No. Design of Animal Experiment. Japanese Name: Unit Size: 100 gm. Wurmbach, E., Chen, Y. The primary antibody of Western Blotting experiment is anti-MMP9 (ab76003, Abcam, UK) and internal reference antibody is Beta Actin Monoclonal antibody (66009-1, Proteintech, United States). Ge xia zhu yu tanguy. Esophageal varicies.

Ling Zhi, and Yan Hu Suo quicken the blood and dispel stasis. A single formula, alone, may not be sufficient to fully address a particular TCM diagnostic pattern. The control and the model groups were given distilled water gavage, and the GXZY group was given a clinically equivalent dose of GXZY solutions by gavage. The Stomach is a so-called "Fu" Organ. Its mechanisms could be related to reducing the expression of MMP9, and pathways such as pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway. Finally, the experiments of Western Blotting and qRT-PCR were used to verify the expression of key target genes. Ge Xia Zhu Yu Wan | Stasis in the Lower Chamber Teapills. This pattern leads to symptoms such as dark face, purple lips, boring fixed stabbing pain and abdominal masses. Formulas may be used alone, in combinations, and/or in stages. Identification of LC Targets. It is one of the most important diagnostic conditions in Chinese Medicine because it is frequently the cause of intractable pain syndromes anywhere in the... read more about Blood Stagnation.

Wu Yao, Yan Hu Suo, Zhi Qiao and Xiang Fu: promoting the circulation of qi and blood, alleviating pain. We found that the mechanisms of GXZY may be related to the pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway derived from network pharmacology analysis. Stiffness, pain, and/or tightness of the neck. The reverse transcription of total RNA to cDNA was performed with qPCR RT Master Mix kit (TOYOBO, JAN). Ethnopharmacol 199, 205–210. In general Yan Hu Suo's main actions are as follows: "Moves the Blood, breaks Blood Stagnation and reduces associated pain. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Ge xia zhu yu tang. Representations Herbal products are food supplements. Pulse type(s): Wiry (Xian). Promotes movement of Qi and alleviates pain - chest pain, abdominal pain, menstrual pain, hernial disorders, epiga…. Yan Hu Suo (Rhizoma Corydalis), 4. JZ analyzed data, and YL revised the manuscript.

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We took the excess median of BC, CNC, DC, LAC, NC, and SC to obtain hub network (Xiao et al., 2015). Qi Stagnation can cause the... read more about Qi And Blood Stagnation. The GO function enrichment and KEGG pathway enrichment were analyzed by DAVID database () (Dennis et al., 2003). ALP Alkaline phosphatase. There was no significant difference in liver weight between 3 groups (Figure 4B). T330203024, Neimenggu, China; 9g), and Faeces Trogopterori (Wulingzhi in Chinese, No. Furthermore, these key genes were related to pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway.

The CCK-8 result showed that, after treatment with different concentrations of the GXZY, the cell viability was significantly decreased in dose-dependent (Figure 8A). Yuan, J., Wei, F., Luo, X., Zhang, M., Qiao, R., Zhong, M., et al. Clears Heat and dispels toxicity. RELA is related to inflammation, immune response, and cell proliferation. With Dang Gui, Tao Ren and Hong Hua, for abdominal pain accompanying menstruation, Pain due to trauma and headache from Blood Stagnation.

Specification: 60tablets per bottle. Signs & symptoms of blood. Drug Design, Development and Therapy 13, 1889–1900. At the end of the 12th week, after 12 h of fasting, the experimental animals were taken to observe the body weight and condition of liver, and the largest lobe of liver tissue 1 cm from the liver border was taken for HE and Sirius red pathological sections. For example, Etsy prohibits members from using their accounts while in certain geographic locations.